TGF-β gene polimorphisms as risk factors for asthma control among clinic patients

Abstract Background TGF-β and its receptors play a crucial role in asthma pathogenesis, bronchial hyperreactivity, remodeling. Expression of isoforms 1–3 TGFβ cytokine is influenced by tagging polymorphisms the TGFβ1, TGFβ2 TGFβ3 gene, these SNPs may be associated with risk development severity as well other diseases. Polymorphic forms TGF-β1, TGF-β2 TGF-β3 genes regulate degree inflammation, deterioration lung functional parameters spirometry elevated level total IgE. All this results intensification disease symptoms. According to current GINA 2020 guidelines, Asthma Control Test (ACT™) should applied assess Methods An analysis localized was conducted on 652 DNA samples an application MassARRAY® system using mass spectrometry technique MALDI TOF MS. The control evaluated ACT™. Results occurrence T / C genotype rs8109627 ( p = 0.0171) TGF-β1 gene significantly higher ACT result (controlled asthma) multivariate linear regression model after backward stepwise selection variables. In addition, for prediction score we showed SNP 0.0497) (improvement - controlled rs2796822 0.0454) (deterioration diseases uncontrolled modify control. Discussion We described clinical significance two TGF-β2, yet unknown. proved that use both genotypes MAC allows create moderately correct prognostic which about 70% efficient entire set analyzed genes.